Diagnostic Criteria for A.S.I.A. Syndrome

Autoimmune/Autoinflammatory Syndrome Induced by an Adjuvant

Per Cohen Tervaert

Major Criteria
  • Exposure to an external stimulus (infection, vaccine, silicone, adjuvant) prior to clinical manifestations
  • The appearance of ‘typical’ clinical manifestations
    • Myalgia, Myositis or muscle weakness
    • Arthralgia and/or arthritis
    • Chronic fatigue, un-refreshing sleep or sleep disturbances
    • Neurological manifestations (especially associated with demyelination)
    • Cognitive impairment, memory loss
    • Pyrexia, dry mouth
  • Removal of inciting agent induces improvement
  • Typical biopsy of involved organs
Minor Criteria
  • The appearance of autoantibodies or antibodies directed at the suspected adjuvant
  • Other clinical manifestations (i.e. irritable bowel syndrome)
  • Specific HLA (i.e. HLA DRB1, HLA DQB1)
  • Evolvement of an autoimmune disease (i.e. multiple sclerosis, systemic sclerosis)

"Patients are considered to have ASIA when either two major or one major and two minor criteria are present."

References

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