Central pain sensitization

Central pain sensitization is a sensitization of the central nervous system that can causes allodynia, hyperalgesia and widening of the pain field. The theory has very compeling evidence from functional MRI studies, specialized histological studies of neural pathways of the dorsal horn of the spinal column, studies of NMDA receptors in these pathways and animal studies. It is accepted as scientific fact in research communities but is virtually unacknowledged in clinical practice

Central pain sensitization is caused by exposure of the central nervous system to intense pain signals from the peripheral nervous system over a long period of time. This results in changes of pain neural pathways in the central nervous system which causes pain to be percieved when there is no peripheral injury, causes amplication of pain coming from minor injury and causes widening of the pain field by recruitment of nearby nerves in the pain pathway.

Central sensitization in urogynecological chronic pelvic pain: a systematic literature review.
Chronic Pelvic Pain: Assessment, Evaluation, and Objectivation

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